TCL065

TCL065 is an ionizable lipid with a pKa of 6.3. TCL065 can be used to generate lipid nanoparticles (LNPs) for the delivery of mRNA as well as single-guide RNA (sgRNA) both in vitro and in vivo. TCL065-containing LNPs can studied in research for Duchenne muscular dystrophy and gene-editing technologies[1].

Product Specifications

CAS Number

[1872269-57-2]

UNSPSC

12352211

Target

Liposome

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Metabolic Disease; Inflammation/Immunology

Smiles

O=C(CCCCN(C)C)OCC(COC(CC(CCCCC)CCCCC)=O)(COC(CC(CCCCC)CCCCC)=O)COC(CC(CCCCC)CCCCC)=O

Molecular Formula

C51H97NO8

Molecular Weight

852.32

References & Citations

[1]Kenjo, E., et al., (2021) . Low immunogenicity of LNP allows repeated administrations of CRISPR-Cas9 mRNA into skeletal muscle in mice. Nature communications, 12 (1), 7101.