SW016789
SW016789 is a hypersecretion-inducer targeting VDAC1. SW016789 can induce insulin hypersecretion and Ca2+ influx in β-cells directly. SW016789 induces a transient endoplasmic reticulum stress response (ER stress), but does not cause beta cell death. SW016789 has reversible and non-apoptotic characteristics. SW016789 can be used for the study of Diabetes mellitus type 2 (T2DM) β-cell dysfunction[1][2].
Product Specifications
CAS Number
[292613-04-8]
UNSPSC
12352005
Target
VDAC
Related Pathways
Membrane Transporter/Ion Channel
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Endocrinology; Metabolic Disease
Purity
99.85
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
N=C1N(C2=CC=CC=C2N1CC(C3=CC=CS3)O)CC4=CC=CC=C4
Molecular Formula
C20H19N3OS
Molecular Weight
349.45
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
VDAC1
Available Sizes
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