Tubulin polymerization-IN-81
Tubulin polymerization-IN-81 is a selective Tubulin inhibitor with an IC50 of 5.41 μM. Tubulin polymerization-IN-81 possesses a significant anti-proliferative activity, unique ROS-mediated apoptotic mechanism and potent anti-microtubule activity. Tubulin polymerization-IN-81 can be used in anti-tumor research[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Microtubule/Tubulin
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=CN1N=C(C2=CC=CC=C2)CC1C3=CN(C4=CC=C([N+]([O-])=O)C=C4)N=C3C5=CC=C(OC)C(OC)=C5
Molecular Formula
C27H23N5O5
Molecular Weight
497.50
References & Citations
[1]Omar MH et al. Design, synthesis, and biological evaluation of pyrazole-based combretastatin A-4 analogues as potential cytotoxic agents. Bioorg Chem. 2025 Jun 16;163:108691.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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