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Tubulin polymerization-IN-81

Tubulin polymerization-IN-81 is a selective Tubulin inhibitor with an IC50 of 5.41 μM. Tubulin polymerization-IN-81 possesses a significant anti-proliferative activity, unique ROS-mediated apoptotic mechanism and potent anti-microtubule activity. Tubulin polymerization-IN-81 can be used in anti-tumor research[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; Microtubule/Tubulin

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

O=CN1N=C(C2=CC=CC=C2)CC1C3=CN(C4=CC=C([N+]([O-])=O)C=C4)N=C3C5=CC=C(OC)C(OC)=C5

Molecular Formula

C27H23N5O5

Molecular Weight

497.50

References & Citations

[1]Omar MH et al. Design, synthesis, and biological evaluation of pyrazole-based combretastatin A-4 analogues as potential cytotoxic agents. Bioorg Chem. 2025 Jun 16;163:108691.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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