PROTAC Bcl-xL degrader-4
PROTAC Bcl-xL degrader-4 (Compound 2-38-III) is a Bcl-xL PROTAC degrader. PROTAC Bcl-xL degrader-4 has strong anti-tumor activity against HepG2 cells and HUVEC cells. PROTAC Bcl-xL degrader-4 induces cells apoptosis by decreasing mitochondrial membrane potential and activating the MAPK signaling pathway. PROTAC Bcl-xL degrader-4 significantly inhibits tumor growth in xenograft tumor mouse models[1]. Pink: MAPK ligand (HY-176741) ; Blue: CRBN ligase ligand (HY-10984) ; Black: linker (HY-W017440)
Product Specifications
CAS Number
[2930759-37-6]
UNSPSC
12352211
Target
Apoptosis; Bcl-2 Family; ERK; JNK; Mitochondrial Metabolism; p38 MAPK; PROTACs; Reactive Oxygen Species (ROS)
Related Pathways
Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB; PROTAC; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
O=C1N(C(C2=CC=CC(NCCOCCOCCOC(C3=CC4=C(NC(C5=CC=CC6=C5C=CC=C6)=CC4=O)C=C3)=O)=C21)=O)C7CCC(NC7=O)=O
Molecular Formula
C39H34N4O9
Molecular Weight
702.71
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Bcl-2; Bcl-xL
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