TGF-β1/Smad-IN-1
TGF-β1/Smad-IN-1 (compound C9) is a potent TGF-β1/Smad inhibitor. TGF-β1/Smad-IN-1 inhibits the expression of fibrosis markers (α-SMA and COL1A1) induced by TGF-β1. TGF-β1/Smad-IN-1 shows antifibrotic effects. TGF-β1/Smad-IN-1 has the potential for the research of hepatic fibrosis[1].
Product Specifications
UNSPSC
12352211
Target
TGF-beta/Smad
Related Pathways
Stem Cell/Wnt; TGF-beta/Smad
Field of Research
Inflammation/Immunology
Smiles
COC(C1=CO[C@H](C2C(CNC3=CC(Cl)=C(C=C3)[N+]([O-])=O)=CCC12)OC)=O
Molecular Formula
C18H19ClN2O6
Molecular Weight
394.81
References & Citations
[1]Cao Y, et al. Design and synthesis of genipine derivatives for the treatment of liver fibrosis by modulating TGF-β1/Smad signaling pathway. Eur J Med Chem. 2025 Jun 15;296:117869.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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