FLT3/IRAK4-IN-1

FLT3/IRAK4-IN-1 is a selective FLT3/IRAK4 inhibitor with the remarkable activity towards FLT3-WT (IC50 = 1.95 nM), FLT3-D835Y (IC50 = 3.22 nM) and IRAK4 (IC50 = 53.72 nM) . LT3/IRAK4-IN-1 has relatively low toxicity to normal bone marrow cells, can effectively promote cell apoptosis, and has the potential to overcome drug resistance. FLT3/IRAK4-IN-1 can be used for research on acute myeloid leukemia (AML) [1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; FLT3; IRAK

Related Pathways

Apoptosis; Immunology/Inflammation; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

FC1=CC=CC(N2C=CC3=C2N=C(N=C3)NC4=CC(N[C@H]5CCNC5)=CC=C4)=C1

Molecular Formula

C22H21FN6

Molecular Weight

388.44

References & Citations

[1]Yuan H et al. Discovery of pyrrolo[2,3-d]pyrimidine derivatives as novel FLT3/IRAK4 inhibitors. Eur J Med Chem. 2025 Jun 13;296:117845. doi: 10.1016/j.ejmech.2025.117845. Epub ahead of print. PMID: 40532500. https://pubmed.ncbi.nlm.nih.gov/40532500/|[2]Yuan H et al. Discovery of pyrrolo[2,3-d]pyrimidine derivatives as novel FLT3/IRAK4 inhibitors. Eur J Med Chem. 2025 Jun 13;296:117845. doi: 10.1016/j.ejmech.2025.117845. Epub ahead of print. PMID: 40532500.