HDAC6-IN-61

HDAC6-IN-61 (Compound 4e) is a HDAC6 inhibitor (IC50: 73 nM) with selectivity over other HDAC isoforms. HDAC6-IN-61 is also a GPR40 activator. HDAC6-IN-61 increases acetylated tubulin and ERK phosphorylation levels. HDAC6-IN-61 can be used for research of neuroinflammation such as Alzheimer's disease[1].

Product Specifications

UNSPSC

12352211

Target

ERK; Free Fatty Acid Receptor; HDAC; Microtubule/Tubulin

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton; Epigenetics; GPCR/G Protein; MAPK/ERK Pathway; Stem Cell/Wnt

Field of Research

Neurological Disease

Smiles

O=C(NO)CCC1=CC=C(C=C1)NCC2=CC3=C(S2)C=CC=C3

Molecular Formula

C18H18N2O2S

Molecular Weight

326.41

References & Citations

[1]Pinheiro PSM, et al. Design, synthesis and pharmacological evaluation of multitarget GPR40 agonists/HDAC6 inhibitors for Alzheimer's disease. Eur J Med Chem. 2025 Jun 13;296:117868.