WRN inhibitor 19
WRN inhibitor 19 (Compound 40) is a WRN helicase inhibitor (IC50: 3.7 nM) . WRN inhibitor 19 exhibits selective antiproliferative activity in WRN-dependent cancer cells. WRN inhibitor 19 inhibits WRN helicase function by competitively binding to the ATP site and induces DNA damage and cell cycle arrest. WRN inhibitor 19 can be used in the study of WRN-dependent cancers[1].
Product Specifications
UNSPSC
12352005
Target
DNA/RNA Synthesis
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Smiles
CN(C([C@H](NC([C@@H]1CN(CC[C@@H]1NC(CCN2C(NC3=C2C=CC(CC(C)(O)C)=C3)=O)=O)C(CC4=CC=C(C=C4F)C(F)(F)F)=O)=O)CC5CCCCC5)=O)C
Molecular Formula
C40H52F4N6O6
Molecular Weight
788.87
References & Citations
[1]Tong Y, et al. Validation, Key Pharmacophores, and X-ray Cocrystal Structures of Novel Biochemically and Cellularly Active WRN Inhibitors Derived from a DNA-Encoded Library Screen. J Med Chem. 2025 Jun 5.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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