WRN inhibitor 19

WRN inhibitor 19 (Compound 40) is a WRN helicase inhibitor (IC50: 3.7 nM) . WRN inhibitor 19 exhibits selective antiproliferative activity in WRN-dependent cancer cells. WRN inhibitor 19 inhibits WRN helicase function by competitively binding to the ATP site and induces DNA damage and cell cycle arrest. WRN inhibitor 19 can be used in the study of WRN-dependent cancers[1].

Product Specifications

UNSPSC

12352005

Target

DNA/RNA Synthesis

Related Pathways

Cell Cycle/DNA Damage

Field of Research

Cancer

Smiles

CN(C([C@H](NC([C@@H]1CN(CC[C@@H]1NC(CCN2C(NC3=C2C=CC(CC(C)(O)C)=C3)=O)=O)C(CC4=CC=C(C=C4F)C(F)(F)F)=O)=O)CC5CCCCC5)=O)C

Molecular Formula

C40H52F4N6O6

Molecular Weight

788.87

References & Citations

[1]Tong Y, et al. Validation, Key Pharmacophores, and X-ray Cocrystal Structures of Novel Biochemically and Cellularly Active WRN Inhibitors Derived from a DNA-Encoded Library Screen. J Med Chem. 2025 Jun 5.