ZnPc-O3-JQ1

ZnPc-O3-JQ1 is a light-triggered BRD4 degrader. Under illumination, ZnPc-O3-JQ1 generates reactive oxygen species (ROS) that degrades BRD4. The degradation of BRD4 results in downregulation of HIF-1α, thereby counteracting the photodynamic therapy (PDT) resistance induced by tumor hypoxia. ZnPc-O3-JQ1 exhibits both Type I and Type II PDT mechanisms. The structure of ZnPc-O3-JQ1 consists of three parts: BRD4 ligand (HY-78695) ; Linker (HY-W040165) ; Photosensitizer (HY-176725) [1].

Product Specifications

UNSPSC

12352211

Target

Epigenetic Reader Domain; HIF/HIF Prolyl-Hydroxylase; Reactive Oxygen Species (ROS)

Related Pathways

Epigenetics; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Field of Research

Cancer

Smiles

O=C(NC1=CC=C(C=C1)OC2=CC3=C(C4=NC5=[N-]6C(C7=C5C=CC=C7)=NC8=C9C=CC=CC9=C%10N=C%11C%12=C(C%13=[N-]%11[Zn+2](N8%10)6N4C3=N%13)C=CC=C%12)C=C2)CCOCCOCCOCCNC(C[C@@H]%14N=C(C%15=CC=C(Cl)C=C%15)C(C(C)=C(C)S%16)=C%16N%17C%14=NN=C%17C)=O

Molecular Formula

C66H53ClN14O6SZn

Molecular Weight

1271.12

References & Citations

[1]Wang K, et al. Photo-Activated PROTACs for Targeted BRD4 Degradation and Synergistic Photodynamic Therapy in Bladder Cancer. Mol Pharm. 2025 Jun 2;22 (6) :3388-3400.