ZnPc-O3-JQ1
ZnPc-O3-JQ1 is a light-triggered BRD4 degrader. Under illumination, ZnPc-O3-JQ1 generates reactive oxygen species (ROS) that degrades BRD4. The degradation of BRD4 results in downregulation of HIF-1α, thereby counteracting the photodynamic therapy (PDT) resistance induced by tumor hypoxia. ZnPc-O3-JQ1 exhibits both Type I and Type II PDT mechanisms. The structure of ZnPc-O3-JQ1 consists of three parts: BRD4 ligand ; Linker (HY-W040165) ; Photosensitizer (HY-176725).
Product Specifications
UNSPSC
12352211
Target
Epigenetic Reader Domain; HIF/HIF Prolyl-Hydroxylase; Reactive Oxygen Species (ROS)
Related Pathways
Epigenetics; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Field of Research
Cancer
Smiles
Molecular Formula
C66H53ClN14O6SZn
Molecular Weight
1271.12
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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