AKR1B1/STAT3/SLC7A11-regulator-1
AKR1B1/STAT3/SLC7A11-regulator-1 (5a) is an AKR1B1/STAT3/SLC7A11 regulator that reverses DOX resistance in MCF-7/ADR cells by enhancing ferroptosis activity. AKR1B1/STAT3/SLC7A11-regulator-1 can be used in breast cancer research[1].
Product Specifications
CAS Number
2632263-80-8
UNSPSC
12352211
Target
Aldose Reductase; Amino acid Transporter; Apoptosis; STAT
Related Pathways
Apoptosis; JAK/STAT Signaling; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Stem Cell/Wnt
Field of Research
Cancer
Smiles
CC(N[C@@H](C(NC1CCC(CC1)NC(/C(C#N)=C/C2=CC=C(C=C2)O)=O)=O)COCC3=CC=CC=C3)=O
Molecular Formula
C28H32N4O5
Molecular Weight
504.58
References & Citations
[1]Zhang C, et al. Novel bis-pocket binding aldose reductase inhibitors sensitize MCF-7/ADR cells to doxorubicin in a dual-role manner. Bioorg Chem. 2025 Apr;157:108286.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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