AKR1B1/STAT3/SLC7A11-regulator-1

AKR1B1/STAT3/SLC7A11-regulator-1 (5a) is an AKR1B1/STAT3/SLC7A11 regulator that reverses DOX resistance in MCF-7/ADR cells by enhancing ferroptosis activity. AKR1B1/STAT3/SLC7A11-regulator-1 can be used in breast cancer research[1].

Product Specifications

CAS Number

[2632263-80-8]

UNSPSC

12352211

Target

Aldose Reductase; Amino acid Transporter; Apoptosis; STAT

Related Pathways

Apoptosis; JAK/STAT Signaling; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Stem Cell/Wnt

Field of Research

Cancer

Smiles

CC(N[C@@H](C(NC1CCC(CC1)NC(/C(C#N)=C/C2=CC=C(C=C2)O)=O)=O)COCC3=CC=CC=C3)=O

Molecular Formula

C28H32N4O5

Molecular Weight

504.58

References & Citations

[1]Zhang C, et al. Novel bis-pocket binding aldose reductase inhibitors sensitize MCF-7/ADR cells to doxorubicin in a dual-role manner. Bioorg Chem. 2025 Apr;157:108286.