VEGFR-2-IN-69
VEGFR-2-IN-69 (Compound 5A) is a dual inhibitor of VEGFR-2 and Telomerase, which upregulates the expression of caspase 3, caspase 8 and caspase 9, while downregulating CDK-2, CDK-4 and CDK-6. VEGFR-2-IN-69 exhibits an IC50 of 15.46 µM against HCT116 cells[1].
Product Specifications
UNSPSC
12352211
Target
Caspase; CDK; Telomerase; VEGFR
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
CC1=C(N=NN1C2=CC=C(C=C2)Cl)C(N/N=C(C3=CC=CC=C3)\C)=O
Molecular Formula
C18H16ClN5O
Molecular Weight
353.81
References & Citations
[1]Ahmed A Al-Karmalawy, et al. Design and synthesis of new 1,2,3-triazole derivatives as VEGFR-2/telomerase downregulatory candidates endowed with apoptotic potential for cancer treatment. Bioorg Chem. 2025 Mar:156:108159.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Caspase 3; Caspase 8; Caspase 9; CDK2; CDK4; CDK6
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