ALDH2 activator 1
ALDH2 activator 1 (Compound Z17) is an allosteric aldehyde dehydrogenase 2 (ALDH2) agonist. ALDH2 activator 1 enhances cardiac function and reduces myocardial necrosis in a mouse model of myocardial ischemia-reperfusion. ALDH2 activator 1 is promising for research of cardiovascular diseases such as myocardial infarction (MI) [1].
Product Specifications
CAS Number
[2988020-77-3]
UNSPSC
12352005
Target
Aldehyde Dehydrogenase (ALDH)
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cardiovascular Disease
Purity
98.88
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(NCC1=CC=C(OC)C(F)=C1)C2=C(OCC3CC3)C=CC(N4C=NN=C4)=C2Cl
Molecular Formula
C21H20ClFN4O3
Molecular Weight
430.86
References & Citations
[1]Zhao F, et al. Design, Synthesis, and Protective Effect Evaluation on Myocardial Ischemia of New Triazole Aldehyde Dehydrogenase 2 Activators[J]. ACS Medicinal Chemistry Letters, 2025.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ALDH2
Available Sizes
Curated Selection
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