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Kv7.2 activator-1

Kv7.2 activator-1 (Compound 8) is a Kv7.2/3 activator with an EC50 of 178 nM. Kv7.2 activator-1 has a long half-life of 120 minutes in HLM[1].

Product Specifications

CAS Number

2981435-59-8

UNSPSC

12352211

Target

Potassium Channel

Related Pathways

Membrane Transporter/Ion Channel

Field of Research

Neurological Disease

Smiles

CC1=NC(N2CCOCC2)=NC(CC)=C1C(NCC3=CC=C(F)C=C3)=O

Molecular Formula

C19H23FN4O2

Molecular Weight

358.41

References & Citations

[1]Frieda-Marie Bartz, et al. New KV7.2/3 Channel Activators Exhibit Superior Toxicity and Metabolic Profiles to Flupirtine and Demonstrate Promising In Vivo Analgesic Effects. ACS Chem Neurosci. 2025 Jun 10.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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