Kv7.2 activator-1
Kv7.2 activator-1 (Compound 8) is a Kv7.2/3 activator with an EC50 of 178 nM. Kv7.2 activator-1 has a long half-life of 120 minutes in HLM[1].
Product Specifications
CAS Number
[2981435-59-8]
UNSPSC
12352211
Target
Potassium Channel
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Neurological Disease
Smiles
CC1=NC(N2CCOCC2)=NC(CC)=C1C(NCC3=CC=C(F)C=C3)=O
Molecular Formula
C19H23FN4O2
Molecular Weight
358.41
References & Citations
[1]Frieda-Marie Bartz, et al. New KV7.2/3 Channel Activators Exhibit Superior Toxicity and Metabolic Profiles to Flupirtine and Demonstrate Promising In Vivo Analgesic Effects. ACS Chem Neurosci. 2025 Jun 10.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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