PAD-PF1
PAD-PF1 is a PAD4 inhibitor (IC50: 15.9 µM) . PAD-PF1 binds to an allosteric site of PAD-PF1, which is distinct from substrate and GSK147[1].
Product Specifications
UNSPSC
12352005
Target
Protein Arginine Deiminase
Related Pathways
Epigenetics
Field of Research
Cancer
Smiles
O=C(N1CCCC1)C(N)C2CCN(C3=NC=NC4=C3C(C)=C(C)N4C5=CC=C(Br)C=C5)CC2
Molecular Formula
C25H31BrN6O
Molecular Weight
511.46
References & Citations
[1]Dakin LA, et al. Inhibiting peptidylarginine deiminases (PAD1-4) by targeting a Ca2+ dependent allosteric binding site. Nat Commun. 2025 May 16;16 (1) :4579.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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