GSK147
GSK147 is a PAD4 inhibitor with a Kd of 0.47 µM. GSK147 inhibits Ionomycin induced protein citrullination in human isolated neutrophils[1].
Product Specifications
CAS Number
1550371-16-8
UNSPSC
12352005
Target
Protein Arginine Deiminase
Related Pathways
Epigenetics
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
COC1=C2C(N=C(N2C)C3=CC4=CC=CN=C4N3CC5CC5)=CC(C(N6CC[C@H]([C@H](C6)N)O)=O)=C1
Molecular Formula
C26H30N6O3
Molecular Weight
474.55
References & Citations
[1]Dakin LA, et al. Inhibiting peptidylarginine deiminases (PAD1-4) by targeting a Ca2+ dependent allosteric binding site. Nat Commun. 2025 May 16;16 (1) :4579.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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