GSK147

GSK147 is a PAD4 inhibitor with a Kd of 0.47 µM. GSK147 inhibits Ionomycin (HY-13434) induced protein citrullination in human isolated neutrophils[1].

Product Specifications

CAS Number

[1550371-16-8]

UNSPSC

12352005

Target

Protein Arginine Deiminase

Related Pathways

Epigenetics

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Smiles

COC1=C2C(N=C(N2C)C3=CC4=CC=CN=C4N3CC5CC5)=CC(C(N6CC[C@H]([C@H](C6)N)O)=O)=C1

Molecular Formula

C26H30N6O3

Molecular Weight

474.55

References & Citations

[1]Dakin LA, et al. Inhibiting peptidylarginine deiminases (PAD1-4) by targeting a Ca2+ dependent allosteric binding site. Nat Commun. 2025 May 16;16 (1) :4579.