ISM5939
ISM5939 is an orally active and selective ENPP1 inhibitor with an IC50 of 0.63 nM for 2,3-cGAMP degradation and 9.28 nM for ATP hydrolysis. ISM5939 has antitumor activity[1].
Product Specifications
CAS Number
2965301-60-2
UNSPSC
12352005
Target
Phosphodiesterase (PDE)
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
99.79
Smiles
COC1=C(C2=CC=CC=C2)C3=C(C=N1)N=C(C)N3CC4=C(F)C=C(S(N)(=O)=O)C=N4
Molecular Formula
C20H18FN5O3S
Molecular Weight
427.45
References & Citations
[1]Pu C, et al. Oral ENPP1 inhibitor designed using generative AI as next generation STING modulator for solid tumors. Nat Commun. 2025 May 23;16 (1) :4793.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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