AAK1-IN-10
AAK1-IN-10 (Compound 1-2) is an AAK1 inhibitor. AAK1-IN-10 has significant AAK1 enzyme inhibitory activity (IC50: 9.62 nM) . AAK1-IN-10 mainly exerts its effects by inhibiting the activity of connexin-associated kinase 1 (AAK1) . AAK1-IN-10 has low cardiotoxicity (IC50 = 13.7 μM) . AAK1-IN-10 can be used in the study of diabetic neuropathy and postherpetic pain[1].
Product Specifications
CAS Number
[3083494-45-2]
UNSPSC
12352005
Target
AAK1
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Smiles
FC(F)C1=NC=CC(C2=CC=C(OC[C@](N)(C)C[C@](O)(C)CO)C(C(F)F)=N2)=C1
Molecular Formula
C19H23F4N3O3
Molecular Weight
417.40
References & Citations
[1]Yao Li, et al. Compound capable of inhibiting connexin-associated kinase 1, preparation, and use thereof. WO2025092928. WO. 2025-05-08.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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