PRMT5-MTA-IN-5
PRMT5-MTA-IN-5 (Compound 7) is an orally active, irreversible PRMT5-MTA complex (PRMT5•MTA) inhibitor (IC50=1.15 nM) . PRMT5-MTA-IN-5 blocks arginine methylation and inhibits ribosomal RNA processing and cell cycle-related protein expression. PRMT5-MTA-IN-5 potently inhibits proliferation in MTAP-deficient tumor cells. PRMT5-MTA-IN-5 is promising for research of MTAP-deficient solid tumors, such as liver, breast, and pancreatic cancers[1].
Product Specifications
CAS Number
[3078322-88-7]
UNSPSC
12352005
Target
Histone Methyltransferase
Related Pathways
Epigenetics
Field of Research
Cancer
Smiles
NCC1=NNC(C2=C(C=C)C=C(C3=[C@]([C@]4=C(C#N)C(N5CC(C5)=C)=CC(C)=C4F)N(C)N=C3)C=C21)=O
Molecular Formula
C27H24FN7O
Molecular Weight
481.52
References & Citations
[1]Li Y, et al. Cyano-containing heterocyclic compound and use thereof. WO2025061102A1. 2025-03-27.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PRMT5
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