PRMT5-MTA-IN-4
PRMT5-MTA-IN-4 (Compound 30) is a potent irreversible protein arginine methyltransferase 5 (PRMT5) inhibitor (IC50=8 nM) . PRMT5-MTA-IN-4 blocks arginine methylation, inhibiting ribosomal RNA processing and cell cycle-related protein expression. PRMT5-MTA-IN-4 exhibits antiproliferative activity in multiple tumor cell lines (e.g., IC50=0.3 μM in DLD-1 cells) . PRMT5-MTA-IN-4 is promising for research of hematological malignancies, such as acute myeloid leukemia, diffuse large B-cell lymphoma[1].
Product Specifications
CAS Number
[3025838-18-7]
UNSPSC
12352005
Target
Histone Methyltransferase
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
NCC1=NNC(C2=C(C=C)C=C(C3=[C@]([C@]4=C(C#N)C(OC5(C)CC5)=CC(Cl)=C4F)N(C)N=C3)C=C21)=O
Molecular Formula
C26H22ClFN6O2
Molecular Weight
504.94
References & Citations
[1]Paul Bishop. Building-wall flexible cladding. WO2020008176A1. 2020-01-09.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PRMT5
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