KMR-206
KMR-206 is a potent selective PARP7 inhibitor, with an IC50 of 13.7 nM. KMR-206 increases STAT1 and phospho-Tyr701-STAT1 (pSTAT1) . KMR-206 induces STING degradation, increases type I IFN reporter. KMR-206 exhibits anticancer activity against lung adenocarcinoma. KMR-206 can be used in the research of colon cancer[1].
Product Specifications
CAS Number
[2992741-10-1]
Target
IFNAR; PARP; STAT; STING
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; Immunology/Inflammation; JAK/STAT Signaling; Stem Cell/Wnt
Field of Research
Cancer
Smiles
N#CC1=CC=C(N2CCN(C(C3=CC(CC4=NNC(C5=C4C=C(C#CC)C=C5)=O)=CC=C3F)=O)CC2)N=C1
Molecular Formula
C29H23FN6O2
Molecular Weight
506.53
References & Citations
[1]Sanderson DJ, et al. Structurally distinct PARP7 inhibitors provide new insights into the function of PARP7 in regulating nucleic acid-sensing and IFN-β signaling. Cell Chem Biol. 2023 Jan 19;30 (1) :43-54.e8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IFNAR1; PARP7; STAT1
Curated Selection
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