Mol4
Mol4 (AK-918/41759663) is a highly selective BCL-2 protein inhibitor (IC50=153.3 μM) . Mol4 induces mitochondrial outer membrane permeabilization (MOMP) and cytochrome c release, showing significant antiproliferative activity against glioblastoma (U87-MG) cell lines. Mol4 is promising for research of BCL-2-dependent tumors (e.g., chronic lymphocytic leukemia) [1].
Product Specifications
CAS Number
512800-53-2
Product Name Alternative
AK-918/41759663
Target
Bcl-2 Family
Related Pathways
Apoptosis
Field of Research
Cancer
Smiles
O=C(C1=CC2=C(C(N(C3=CC=C(SC4=CC=C(C)C=C4)C=C3)C2=O)=O)C=C1)OCC(C5=CC=C(Cl)C=C5)=O
Molecular Formula
C30H20ClNO5S
Molecular Weight
542.00
References & Citations
[1]Sahin K, et al. Hybrid In Silico and TR-FRET-Guided Discovery of Novel BCL-2 Inhibitors. ACS Pharmacol Transl Sci. 2021 Apr 15;4 (3) :1111-1123.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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