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Apiol analog-1

Apiol analog-1 (Compound 2b) is an analog of Apiol. Apiole is an anti-tumor agent that induces apoptosis and inhibits human colon cancer cells by inducing G0/G1 cell cycle arrest. Apiole also significantly inhibited colon tumor development in an in vivo mouse xenograft model[1][2][3].

Product Specifications

CAS Number

484-52-6

Target

Apoptosis

Related Pathways

Apoptosis

Field of Research

Cancer

Smiles

C/C=C/C1=CC(OC)=C(OCO2)C2=C1OC

Molecular Formula

C12H14O4

Molecular Weight

222.24

References & Citations

[1]Titov IY, et al. Application of plant allylpolyalkoxybenzenes in synthesis of antimitotic phenstatin analogues. Bioorg Med Chem Lett. 2011 Mar 15;21 (6) :1578-81.|[2]Wu KH, et al. Study of the antitumor mechanisms of apiole derivatives (AP-02) from Petroselinum crispum through induction of G0/G1 phase cell cycle arrest in human COLO 205 cancer cells. BMC Complement Altern Med. 2019 Jul 27;19 (1) :188. |[3]Wei PL, et al. The in vivo antitumor effects on human COLO 205 cancer cells of the 4,7-dimethoxy-5- (2-propen-1-yl) -1,3-benzodioxole (apiole) derivative of 5-substituted 4,7-dimethoxy-5-methyl-l,3-benzodioxole (SY-1) isolated from the fruiting body of Antrodia camphorate. J Cancer Res Ther. 2012 Oct-Dec;8 (4) :532-6.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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