LCL768
LCL768 is a ceramide analog. LCL768 attenuates PARKIN succination to promote PARKIN activation and mitophagy. LCL768 induces CerS1-mediated endogenous C18-ceramide accumulation in mitochondria to mediate mitophagy, which is dependent on DRP1 activation via nitrosylation at C644. LCL768 alters mitochondrial metabolism, resulting in fumarate depletion and leading to tumor suppression. LCL768 improves sensorimotor defects in neurodegenerative diseases like ALS[1][2].
Product Specifications
UNSPSC
12352211
Target
Mitochondrial Metabolism; Mitophagy; PINK1/Parkin
Related Pathways
Autophagy; Metabolic Enzyme/Protease; Neuronal Signaling
Field of Research
Cancer; Neurological Disease
Smiles
OC[C@H](NC(CCCCCCCCCCCCCCCCC)=O)[C@H](O)/C=C/CCCCCCCCC[N+]1=CC=CC=C1.[O-][Se]([O-])=O.[1/2]
Molecular Formula
C37H67N2O3.1/2SeO3
Molecular Weight
651.42
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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