LCL768

LCL768 is a ceramide analog. LCL768 attenuates PARKIN succination to promote PARKIN activation and mitophagy. LCL768 induces CerS1-mediated endogenous C18-ceramide accumulation in mitochondria to mediate mitophagy, which is dependent on DRP1 activation via nitrosylation at C644. LCL768 alters mitochondrial metabolism, resulting in fumarate depletion and leading to tumor suppression. LCL768 improves sensorimotor defects in neurodegenerative diseases like ALS[1][2].

Product Specifications

UNSPSC

12352211

Target

Mitochondrial Metabolism; Mitophagy; PINK1/Parkin

Related Pathways

Autophagy; Metabolic Enzyme/Protease; Neuronal Signaling

Field of Research

Cancer; Neurological Disease

Smiles

OC[C@H](NC(CCCCCCCCCCCCCCCCC)=O)[C@H](O)/C=C/CCCCCCCCC[N+]1=CC=CC=C1.[O-][Se]([O-])=O.[1/2]

Molecular Formula

C37H67N2O3.1/2SeO3

Molecular Weight

651.42

References & Citations

[1]Oleinik N, et al. Alterations of lipid-mediated mitophagy result in aging-dependent sensorimotor defects. Aging Cell. 2023 Oct;22 (10) :e13954.|[2]Oleinik NV, et al. Ceramide-Induced Metabolic Stress Depletes Fumarate and Drives Mitophagy to Mediate Tumor Suppression. Cancer Res. 2025 Jun 20