NCI677397

NCI677397 is a USP24 inhibitor. NCI677397 increases lipid ROS, activates cholesterol and fatty acid biosynthesis, degrades ABC transporters, GPX4 and DHFR through the autophagy pathway, decreases the level of P-gp and ultimately leads to ferroptosis in drug-resistant cancer cells. NCI677397 can be used for the study of lung caner and brain cancer[1][2].

Product Specifications

CAS Number

[907547-06-2]

UNSPSC

12352005

Target

Autophagy; Deubiquitinase; Ferroptosis; Glutathione Peroxidase; Reactive Oxygen Species (ROS)

Related Pathways

Apoptosis; Autophagy; Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

O=C(C1=CC=C2SC3=C(N(CCCCN4CCN(CC4)C)C2=C1)C=CC=C3)C5=CC=CC=C5

Molecular Formula

C28H31N3OS

Molecular Weight

457.63

References & Citations

[1]led to smaller tumor size and lower tumor weight.|[2]Wang SA, et al. USP24 promotes drug resistance during cancer therapy. Cell Death Differ. 2021 Sep;28 (9) :2690-2707.