SEH-IN-21
SEH-IN-21 is an orally active sEH inhibitor with IC50s of 0.1 nM for hsEH and msEH. sEH-IN-21 potently inhibits NF-κB signaling pathways. sEH-IN-21 shows a strong anti-inflammatory activity, decreases the release of IL-6 and TNF-α and maintained the integrity of the intestinal barrier. sEH-IN-21 can be used for the study of inflammatory bowel disease (IBD) [1].
Product Specifications
CAS Number
[3084814-46-7]
UNSPSC
12352211
Target
Epoxide Hydrolase; Interleukin Related; NF-κB; TNF Receptor
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease; Inflammation/Immunology
Smiles
O=C1C(N[C@@H]2CC[C@@H](NC(N[C@]3(C4)C[C@H](C5)C[C@]4(C)C[C@@]5(C)C3)=O)CC2)=C(NS(C6=CC=C(C)C=C6)(=O)=O)C1=O
Molecular Formula
C30H40N4O5S
Molecular Weight
568.73
References & Citations
[1]Xu H, et al. Design and Synthesis of Novel sEH Inhibitors for the Treatment of Inflammatory Bowel Disease. J Med Chem. 2025 Jul 1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IL-6; NF-κB
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