Tubulin polymerization-IN-83

Tubulin polymerization-IN-83 (Compound A23) is a flavonol derivative. Tubulin polymerization-IN-83 exhibits antifungal activity against various phytopathogenic fungi, with an EC50 of 0.338 μg/mL against Botrytis cinerea. Tubulin polymerization-IN-83 exerts its effects by targeting β-tubulin, disrupting mycelial morphology, and increasing cell membrane permeability, with relatively low ecological and environmental risks[1].

Product Specifications

UNSPSC

12352005

Target

Fungal; Microtubule/Tubulin

Related Pathways

Anti-infection; Cell Cycle/DNA Damage; Cytoskeleton

Field of Research

Infection

Smiles

O=C1C(OCC2=NC3=CC=CC=C3N2S(=O)(C4=CC=C(S4)Cl)=O)=C(OC5=C1C=CC=C5)C6=CC=CC=C6

Molecular Formula

C27H17ClN2O5S2

Molecular Weight

549.02

References & Citations

[1]Chen H, et al. Antifungal Activity and Mechanism of Novel Benzimidazole-Containing Flavonol Derivatives as Potential Tubulin Polymerization Inhibitors against Botrytis cinerea. J Agric Food Chem. 2025 Jul 16;73 (28) :17994-18002.