Tubulin polymerization-IN-83
Tubulin polymerization-IN-83 (Compound A23) is a flavonol derivative. Tubulin polymerization-IN-83 exhibits antifungal activity against various phytopathogenic fungi, with an EC50 of 0.338 μg/mL against Botrytis cinerea. Tubulin polymerization-IN-83 exerts its effects by targeting β-tubulin, disrupting mycelial morphology, and increasing cell membrane permeability, with relatively low ecological and environmental risks[1].
Product Specifications
UNSPSC
12352005
Target
Fungal; Microtubule/Tubulin
Related Pathways
Anti-infection; Cell Cycle/DNA Damage; Cytoskeleton
Field of Research
Infection
Smiles
O=C1C(OCC2=NC3=CC=CC=C3N2S(=O)(C4=CC=C(S4)Cl)=O)=C(OC5=C1C=CC=C5)C6=CC=CC=C6
Molecular Formula
C27H17ClN2O5S2
Molecular Weight
549.02
References & Citations
[1]Chen H, et al. Antifungal Activity and Mechanism of Novel Benzimidazole-Containing Flavonol Derivatives as Potential Tubulin Polymerization Inhibitors against Botrytis cinerea. J Agric Food Chem. 2025 Jul 16;73 (28) :17994-18002.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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