ASIC1a antagonist-1
ASIC1a antagonist-1 (Compound 5b) is an orthosteric noncompetitive Acid sensing ion channels 1a (ASIC1a) antagonist with an IC50 of 27 nM (pH 6.7) . ASIC1a antagonist-1 shifts pH dependence of ASIC1a activation and inhibits its maximal evoked response. ASIC1a antagonist-1 completely inhibits long-term potentiation (LTP) induction in CA3-CA1 pathway. ASIC1a antagonist-1 can be used for brain diseases and pathologies research[1].
Product Specifications
CAS Number
[1787243-08-6]
UNSPSC
12352005
Target
Sodium Channel
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Neurological Disease
Purity
98.00
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1OC2=C(C=C1C(N)=N)C=CC(N(CCN(CC)CC)CC3=CC=C(C=C3)Cl)=C2.Cl.Cl
Molecular Formula
C23H29Cl3N4O2
Molecular Weight
499.86
References & Citations
[1]Buta A, et al. Novel Potent Orthosteric Antagonist of ASIC1a Prevents NMDAR-Dependent LTP Induction. J Med Chem. 2015 Jun 11;58 (11) :4449-61.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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