FGFR2/3-IN-3
FGFR2/3-IN-3 is a dual-target FGFR2/3 inhibitor with IC50s of 2.7 nM (TEL-FGFR2) and 3.9 nM (TEL-FGFR3), respectively. FGFR2/3-IN-3 has effective activity against both wild-type and mutant FGFR3. FGFR2/3-IN-3 has low CYP3A4 inhibitory effect and hERG toxicity. FGFR2/3-IN-3 improves the imbalance between chondrocyte proliferation and differentiation and promotes bone growth by inhibiting the signaling pathway mediated by mutant FGFR3. FGFR2/3-IN-3 shows a growth-promoting effect in a dwarfism mouse model and has the potential to study bone development disorder-related diseases such as achondroplasia (ACH) [1].
Product Specifications
CAS Number
3069945-78-1
UNSPSC
12352005
Target
Cytochrome P450; FGFR
Related Pathways
Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Endocrinology
Smiles
CC(C)(CN1N=C(C(C2=NC=C(C=C2F)C3=NNC4=C3C=C(C(C)=C4)O[C@H](C)C5=C(C=NC=C5Cl)Cl)=C1)C)O
Molecular Formula
C28H27Cl2FN6O2
Molecular Weight
569.46
References & Citations
[1]Donglin Fu, et al.ACS Medicinal Chemistry Letters 2025 16 (7), 1428-1434.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CYP2C9; CYP2D6; CYP3; FGFR2; FGFR3
Frequently Asked Questions
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