NK3R-IN-2

NK3R-IN-2 is an orally active NK3R inhibitor with an IC50 of 330.50 nM for human NK3R. NK3R-IN-2 can pass through the blood-brain barrier. NK3R-IN-2 has excellent NK3R binding affinity (IC50 = 87.31 nM) in CHO-K1 cells. NK3R-IN-2 effectively inhibits the level of luteinizing hormone (LH) . NK3R-IN-2 can be used for research on hormone related conditions[1].

Product Specifications

UNSPSC

12352005

Target

Neurokinin Receptor

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology

Smiles

N#CC1=C2C(C)N(C(C3=CC=C(Cl)C(F)=C3)=O)CCN2C(C4=NC(C)=NS4)=N1

Molecular Formula

C18H14ClFN6OS

Molecular Weight

416.86

References & Citations

[1]Shengmin Ji, et al. Development of a Highly Potent Neurokinin-3 Receptor Inhibitor: Design, Synthesis, and Evaluation. ACS Med. Chem. Lett. 2025, 16, 1373-1382.