NK3R-IN-2
NK3R-IN-2 is an orally active NK3R inhibitor with an IC50 of 330.50 nM for human NK3R. NK3R-IN-2 can pass through the blood-brain barrier. NK3R-IN-2 has excellent NK3R binding affinity (IC50 = 87.31 nM) in CHO-K1 cells. NK3R-IN-2 effectively inhibits the level of luteinizing hormone (LH) . NK3R-IN-2 can be used for research on hormone related conditions[1].
Product Specifications
UNSPSC
12352005
Target
Neurokinin Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology
Smiles
N#CC1=C2C(C)N(C(C3=CC=C(Cl)C(F)=C3)=O)CCN2C(C4=NC(C)=NS4)=N1
Molecular Formula
C18H14ClFN6OS
Molecular Weight
416.86
References & Citations
[1]Shengmin Ji, et al. Development of a Highly Potent Neurokinin-3 Receptor Inhibitor: Design, Synthesis, and Evaluation. ACS Med. Chem. Lett. 2025, 16, 1373-1382.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NK3R
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