TD034
TD034 is a selective, reversible and noncovalent HDAC11 inhibitor with an IC50 of 5.1 nM and a Ki of 1.5 nM. TD034 does not inhibit other HDACs or sirtuins. TD034 inhibits the defatty acylation of SHMT2 (HDAC11 substrate) . TD034 decreases the YAP1 level via HDAC11 inhibition. TD034 can be used for the study of lung cancer[1].
Product Specifications
CAS Number
3030718-42-1
UNSPSC
12352211
Target
HDAC; YAP
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; Stem Cell/Wnt
Field of Research
Cancer
Purity
96.49
Smiles
CCCCCCCCCCC[C@@H]1[C@H](O1)C(CCCCC[C@@H]2NC([C@]3([H])N(CCCC3)C([C@@H](NC([C@@H](NC2=O)CC4=CC=CC=C4)=O)CC5=CC=CC=C5)=O)=O)=O
Molecular Formula
C45H64N4O6
Molecular Weight
757.01
References & Citations
[1]Ho TT, et al. Trapoxin A Analogue as a Selective Nanomolar Inhibitor of HDAC11. ACS Chem Biol. 2023 Apr 21;18 (4) :803-809.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC11; YAP1
Available Sizes
Frequently Asked Questions
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