DiABZI-Mal
DiABZI-Mal is a STING agonist with maleimide group, which can be used for the synthesis of conjugates. diABZI-Mal activates cGAS-STING pathway to induce cytokine production such as interferon-type I. diABZI-Mal promotes maturation of DC cells and efficiently induces CD8+ T immune reaction. diABZI-Mal inhibits tumor growth[1].
Product Specifications
CAS Number
[2763540-24-3]
UNSPSC
12352211
Target
STING
Related Pathways
Immunology/Inflammation
Field of Research
Cancer; Inflammation/Immunology
Smiles
O=C(N)C1=CC2=C(N(C(NC(C3=CC(C)=NN3CC)=O)=N2)C/C=C/CN4C(NC(C5=CC(C)=NN5CC)=O)=NC6=C4C(OCCCN7CCN(C(CCCCCN8C(C=CC8=O)=O)=O)CC7)=CC(C(N)=O)=C6)C(OC)=C1
Molecular Formula
C52H63N15O9
Molecular Weight
1042.15
References & Citations
[1]Ji Wang, et al. Endoplasmic reticulum Golgi matrix targeting small molecule, conjugate and application thereof. Patent. CN114163420A.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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