PAK1-IN-2
PAK1-IN-2 (Compound 35) is a selective PAK1 inhibitor with a Ki of 7.3 nM. PAK1-IN-2 can inhibit MEK phosphorylation. PAK1-IN-2 has significant inhibitory effects on PAK1/4 amplified cancer cell lines. PAK1-IN-2 can be used in the study of cancer[1].
Product Specifications
UNSPSC
12352005
Target
PAK; PERK
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Field of Research
Cancer
Smiles
CN(C(C1(C#N)CNC1)=O)C2(C3)CC3(C2)NC4=NC(NC5=NC=C(C6CC6)S5)=CC=N4
Molecular Formula
C21H24N8OS
Molecular Weight
436.53
References & Citations
[1]Johns DM, et al. Identification of a p21-activated kinase 1 (PAK1) inhibitor with 10-fold selectivity against PAK2. Bioorg Med Chem Lett. 2025 Jun 12;127:130307.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PAK1
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