Antiproliferative agent-72
Antiproliferative agent-72 (Compound 10) is a Hsp90 inhibitor with a Kd of 11 nM. Antiproliferative agent-72 has antiproliferative activity with IC50s of 1.5 μM and 1.1 μM for HCT116 and NCI-N87 cells, respectively. Antiproliferative agent-72 can be used for cancers research[1].
Product Specifications
CAS Number
[1052646-54-4]
UNSPSC
12352005
Target
HSP
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
ClC1=CC(Cl)=C2C=C1OCCCCOC3=CC=CC(SC4=NC(N)=NC2=C4)=C3
Molecular Formula
C20H17Cl2N3O2S
Molecular Weight
434.34
References & Citations
[1]Suda A, et al. Design and synthesis of novel macrocyclic 2-amino-6-arylpyrimidine Hsp90 inhibitors. Bioorg Med Chem Lett. 2012 Jan 15;22 (2) :1136-41.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HSP90
Curated Selection
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