PRMT5-IN-52

PRMT5-IN-52 (Compound 17) is a non-nucleoside Protein Arginine Methyltransferase 5 (PRMT5) inhibitor with inhibitory rates of 20.2% at 10 μM. PRMT5-IN-52 has potent antitumor activity, promising for research of cancers, including lung, prostate cancer, and colorectal carcinoma[1].

Product Specifications

CAS Number

[2783961-64-6]

UNSPSC

12352005

Target

Histone Methyltransferase

Related Pathways

Epigenetics

Field of Research

Cancer

Smiles

NC1=NC=NC2=C1C=C(C3=CC=C(OCC4=CC=CC=C4)C=C3)N2

Molecular Formula

C19H16N4O

Molecular Weight

316.36

References & Citations

[1]Rong D, et al. Structure-Aided Design, Synthesis, and Biological Evaluation of Potent and Selective Non-Nucleoside Inhibitors Targeting Protein Arginine Methyltransferase 5. J Med Chem. 2022 Jun 9;65 (11) :7854-7875.