PROTAC ERK5 degrader-1
PROTAC ERK5 degrader-1 (compound 2) is a bifunctional ERK5 PROTAC degrader. PROTAC ERK5 degrader-1 induces ERK5 degradation via VHL-mediated proteasome pathway in MOLT-4 cells. PROTAC ERK5 degrader-1 can be used for the study of a disease or disorder characterized by aberrant ERK5 activity (Pink: ERK5 ligand (HY-176529) ; Blue: VHL ligand (HY-42424) ; Black: linker (HY-43191) ; VHL ligand + linker: HY-176530) [1].
Product Specifications
CAS Number
[2919963-24-7]
UNSPSC
12352211
Target
ERK; PROTACs
Related Pathways
MAPK/ERK Pathway; PROTAC; Stem Cell/Wnt
Field of Research
Cancer
Smiles
O=C(C1=C(C=C(C=C1)OC(F)(F)F)N)N2CCC(CC2)C3=NC=NC4=C3C=CC(N5CCN(CC5)CCCCCC(N[C@@H](C(C)(C)C)C(N6[C@@H](C[C@H](C6)O)C(N[C@H](C7=CC=C(C8=C(N=CS8)C)C=C7)C)=O)=O)=O)=C4
Molecular Formula
C54H67F3N10O6S
Molecular Weight
1041.23
References & Citations
[1]Inchul YOU, et al. Erk5 degraders and uses thereof. WO2023044482A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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