PROTAC ERK5 degrader-1
PROTAC ERK5 degrader-1 (compound 2) is a bifunctional ERK5 PROTAC degrader. PROTAC ERK5 degrader-1 induces ERK5 degradation via VHL-mediated proteasome pathway in MOLT-4 cells. PROTAC ERK5 degrader-1 can be used for the study of a disease or disorder characterized by aberrant ERK5 activity (Pink: ERK5 ligand ; Blue: VHL ligand (HY-42424) ; Black: linker (HY-43191) ; VHL ligand + linker: HY-176530).
Product Specifications
CAS Number
2919963-24-7
UNSPSC
12352211
Target
ERK; PROTACs
Related Pathways
MAPK/ERK Pathway; PROTAC; Stem Cell/Wnt
Field of Research
Cancer
Smiles
O=C(C1=C(C=C(C=C1)OC(F)(F)F)N)N2CCC(CC2)C3=NC=NC4=C3C=CC(N5CCN(CC5)CCCCCC(N[C@@H](C(C)(C)C)C(N6[C@@H](C[C@H](C6)O)C(N[C@H](C7=CC=C(C8=C(N=CS8)C)C=C7)C)=O)=O)=O)=C4
Molecular Formula
C54H67F3N10O6S
Molecular Weight
1041.23
References & Citations
[1]Inchul YOU, et al. Erk5 degraders and uses thereof. WO2023044482A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
ARP6443-01 10 µg
Recombinant Mouse SDPR Protein (aa 2-180, His tag)
Sign In for Pricing
View Details ARP6443-02 50 µg
Recombinant Mouse SDPR Protein (aa 2-180, His tag)
Sign In for Pricing
View Details ARP6443-03 100 µg
Recombinant Mouse SDPR Protein (aa 2-180, His tag)
Sign In for Pricing
View Details