BTK degrader-1 intermediate

BTK degrader-1 intermediate (compound 5) is an intermediate for the synthesis of BTK degrader-1 (HY-163295) . BTK degrader-1 can be used as an ADC toxin to synthesize antibody-drug conjugate (ADC) [1].

Product Specifications

CAS Number

[2377643-84-8]

UNSPSC

12352005

Target

Btk; Drug Intermediate

Related Pathways

Others; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

O=C(C1=CC=C(C(C)(C)O)C=C1F)NC2=CC(F)=CC(C3=C4C=C(C5=CC=C(CCN6CCC7(CC6)CCNCC7)C=C5)NC4=NC=N3)=C2C

Molecular Formula

C40H44F2N6O2

Molecular Weight

678.81

References & Citations

[1]Zhang A, et al. Design, Synthesis, and In Vitro and In Vivo Evaluation of Cereblon Binding Bruton's Tyrosine Kinase (BTK) Degrader CD79b Targeted Antibody-Drug Conjugates. Bioconjug Chem. 2024 Feb 21;35 (2) :140-146.