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Antiproliferative agent-71

Antiproliferative agent-71 (Compound II-5) is an orally active dual inhibitor against the androgen receptor (AR) and bromodomain-containing protein 4 (BRD4) . Antiproliferative agent-71 effectively inhibits tumor cell growth and proliferation by simultaneously blocking the functions of AR and BRD4. Antiproliferative agent-71 is promising for research of prostate cancer[1].

Product Specifications

CAS Number

3083307-42-7

UNSPSC

12352005

Target

Androgen Receptor; Epigenetic Reader Domain

Related Pathways

Epigenetics; Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

N#CC1=C(OC)C=C(O[C@@H]2C(C)(C)[C@@H](NC(C3=CN=C(N4CCC5(CC(OC6=CC=C(C7=N[C@@H](CC8=NC=CO8)C9=NN=C(C)N9C%10=C7C(C)=C(C)S%10)C=C6)C5)CC4)N=C3)=O)C2(C)C)C=C1

Molecular Formula

C50H54N10O5S

Molecular Weight

907.09

References & Citations

[1]Kyle J. Eastman, et al. Heterobifunctional compounds and methods of treating disease. WO2025085738A1. 2025-04-24.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

BRD4

Available Sizes

Frequently Asked Questions

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