SsPalmE-P4-C2

SsPalmE-P4-C2 is a SS-cleavable and pH-sensitive lipid-like material (ssPalm) with a vitamin E‑scaffold. ssPalmE-P4-C2 improves gene knockdown activity against FVII with an ED50 of 0.5 mg/kg. ssPalmE-P4-C2 can be used to synthesize lipid nanoparticles (LNPs) for delivering siRNA to the hepatocyte. ssPalmE-P4-C2 can be used for the RNA therapies for dyslipidemia, hepatitis B/C infections and transthyretin amyloidosis research[1].

Product Specifications

CAS Number

[2247153-41-7]

UNSPSC

12352005

Target

Liposome; Ser/Thr Protease

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Infection; Metabolic Disease; Neurological Disease

Smiles

O=C(CCC(OCCC1CCN(CC1)CCSSCCN2CCC(CC2)CCOC(CCC(OC3=C(C)C4=C(OC(CC4)(CCCC(CCCC(CCCC(C)C)C)C)C)C(C)=C3C)=O)=O)=O)OC5=C(C)C6=C(OC(CC6)(CCCC(CCCC(CCCC(C)C)C)C)C)C(C)=C5C

Molecular Formula

C84H140N2O10S2

Molecular Weight

1402.15

References & Citations

[1]Akita H, et al. Molecular Tuning of a Vitamin E-Scaffold pH-Sensitive and Reductive Cleavable Lipid-like Material for Accelerated in Vivo Hepatic siRNA Delivery. ACS Biomater Sci Eng. 2015 Sep 14;1 (9) :834-844.