SsPalmE-P4-C2
SsPalmE-P4-C2 is a SS-cleavable and pH-sensitive lipid-like material (ssPalm) with a vitamin E‑scaffold. ssPalmE-P4-C2 improves gene knockdown activity against FVII with an ED50 of 0.5 mg/kg. ssPalmE-P4-C2 can be used to synthesize lipid nanoparticles (LNPs) for delivering siRNA to the hepatocyte. ssPalmE-P4-C2 can be used for the RNA therapies for dyslipidemia, hepatitis B/C infections and transthyretin amyloidosis research[1].
Product Specifications
CAS Number
2247153-41-7
UNSPSC
12352005
Target
Liposome; Ser/Thr Protease
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Infection; Metabolic Disease; Neurological Disease
Smiles
O=C(CCC(OCCC1CCN(CC1)CCSSCCN2CCC(CC2)CCOC(CCC(OC3=C(C)C4=C(OC(CC4)(CCCC(CCCC(CCCC(C)C)C)C)C)C(C)=C3C)=O)=O)=O)OC5=C(C)C6=C(OC(CC6)(CCCC(CCCC(CCCC(C)C)C)C)C)C(C)=C5C
Molecular Formula
C84H140N2O10S2
Molecular Weight
1402.15
References & Citations
[1]Akita H, et al. Molecular Tuning of a Vitamin E-Scaffold pH-Sensitive and Reductive Cleavable Lipid-like Material for Accelerated in Vivo Hepatic siRNA Delivery. ACS Biomater Sci Eng. 2015 Sep 14;1 (9) :834-844.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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