Adenosine receptor agonist 2

Adenosine receptor agonist 2 (Compound 10) is an adenosine A2B receptor (A2BR) agonist with an EC50 of 0.38 nM. Adenosine receptor agonist 2 significantly inhibits the accumulation of cAMP and calcium. Adenosine receptor agonist 2 can be used for cardioprotection research[1].

Product Specifications

CAS Number

2789709-35-7

UNSPSC

12352005

Target

Adenosine Receptor

Related Pathways

GPCR/G Protein

Field of Research

Cardiovascular Disease

Smiles

OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C3=NC=NC(NCCCCCCN(N=N4)C=C4C(C=C5)=CC=C5C6=C(C7=CC(C(F)(F)F)=CC=C7)C(C(C8=CC=CC=C8)=O)=C(N)S6)=C3N=C2)O1

Molecular Formula

C42H40F3N9O5S

Molecular Weight

839.88

References & Citations

[1]Awalt JK, et al. Examining the Role of the Linker in Bitopic N6-Substituted Adenosine Derivatives Acting as Biased Adenosine A1 Receptor Agonists. J Med Chem. 2022 Jul 14;65 (13) :9076-9095.