NBM-T-BMX-OS01

NBM-T-BMX-OS01 is an Osthole (HY-N0054) derivative. NBM-T-BMX-OS01 inhibits the phosphorylation of VEGFR2, FAK, Akt and ERK. NBM-T-BMX-OS01 has anti-angiogenic activity. NBM-T-BMX-OS01 has anti-cancer activity against colorectal cancer[1].

Product Specifications

CAS Number

[1246952-34-0]

Product Name Alternative

BMX

UNSPSC

12352005

Target

Akt; FAK; PERK; VEGFR

Related Pathways

Cell Cycle/DNA Damage; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

COC(C=C1)=CC=C1COC2=C(C(OC)=CC=C2/C=C/C(NO)=O)C/C=C(C)\C

Molecular Formula

C23H27NO5

Molecular Weight

397.46

References & Citations

[1]Yang HY, et al. Anti-cancer activity of an osthole derivative, NBM-T-BMX-OS01: targeting vascular endothelial growth factor receptor signaling and angiogenesis. PLoS One. 2013 Nov 27;8 (11) :e81592.