PROTAC pan-KRAS degrader-1

PROTAC pan-KRAS degrader-1 is a pan-KRAS PROTAC degrader for degrading different KRAS mutation types, such as G12D, G12C, G12V, and G13D. PROTAC pan-KRAS degrader-1 potently degrades KRAS mutation (G12D) in AGS cells, with a DC50 of 1.1 nM, Dmax of 95%. PROTAC pan-KRAS degrader-1 can be used to search diseases caused by KRAS mutation or amplification, especially cancers such as breast cancer, bladder cancer, gastric cancer, etc[1]. Pink: pan-KRAS ligand (HY-176490) ; Blue: VHL ligase ligand (HY-170353) ; Black: linker (HY-176491)

Product Specifications

CAS Number

[3043908-63-7]

UNSPSC

12352005

Target

PROTACs; Ras

Related Pathways

GPCR/G Protein; MAPK/ERK Pathway; PROTAC

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

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