SARM1-IN-6
SARM1-IN-6 (Compound 22b) is a brain-permeable SARM1 orthosteric inhibitor, the IC50 of SARM1-IN-6 against NAM is 0.069 μM[1].
Product Specifications
CAS Number
[3080315-51-8]
UNSPSC
12352005
Target
Toll-like Receptor (TLR)
Related Pathways
Immunology/Inflammation
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Smiles
O=C1N(CC[C@H](C2=CN=C(F)C(F)=C2)C1)C34CC(C4)(C5=CC=NC=C5)C3
Molecular Formula
C20H19F2N3O
Molecular Weight
355.38
References & Citations
[1]Samantha A. Green, et al. Optimization of Brain Penetrant SARM1 Orthosteric Inhibitors and Discovery of Their Paradoxical Subinhibitory Activation. ACS. Vol 16/Issue 6. May 20, 2025.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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