ER degrader 11
ER degrader 11 (Compound 5) is an orally active, brain-penetrant and selective estrogen receptor (ER) degrader (ERα IC50=1.6 nM) . ER degrader 11 is promising for research of breast cancer brain metastasis[1].
Product Specifications
CAS Number
2770911-29-8
UNSPSC
12352005
Target
Estrogen Receptor/ERR
Related Pathways
Vitamin D Related/Nuclear Receptor
Field of Research
Cancer
Smiles
C[C@H](CC1=C2NC3=CC=CC=C31)N([C@@H]2C4=C(C=C(C=C4F)NC5CN(C5)CCCF)F)C67CC(C7)C6
Molecular Formula
C29H33F3N4
Molecular Weight
494.59
References & Citations
[1]Zhang G, et al. Discovery of an Orally Bioavailable and Brain Penetrant Selective Estrogen Receptor Degrader. J Med Chem. 2025 Jun 12;68 (11) :11990-12003.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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