ER degrader 11

ER degrader 11 (Compound 5) is an orally active, brain-penetrant and selective estrogen receptor (ER) degrader (ERα IC50=1.6 nM) . ER degrader 11 is promising for research of breast cancer brain metastasis[1].

Product Specifications

CAS Number

[2770911-29-8]

UNSPSC

12352005

Target

Estrogen Receptor/ERR

Related Pathways

Vitamin D Related/Nuclear Receptor

Field of Research

Cancer

Smiles

C[C@H](CC1=C2NC3=CC=CC=C31)N([C@@H]2C4=C(C=C(C=C4F)NC5CN(C5)CCCF)F)C67CC(C7)C6

Molecular Formula

C29H33F3N4

Molecular Weight

494.59

References & Citations

[1]Zhang G, et al. Discovery of an Orally Bioavailable and Brain Penetrant Selective Estrogen Receptor Degrader. J Med Chem. 2025 Jun 12;68 (11) :11990-12003.