Antiproliferative agent-70

Antiproliferative agent-70 (compound 23) is a potent antiproliferative agent. Antiproliferative agent-70 shows antiproliferative activities and induces MMP depolarization. Antiproliferative agent-70 induces mitochondrial dysfunction. Antiproliferative agent-70 induces mitophagy and ferroptosis. Antiproliferative agent-70 increases the protein expression of PINK1, p-Parkin, p53 and p21. Antiproliferative agent-70 increases intracellular ROS levels. Antiproliferative agent-70 shows anticancer activity[1].

Product Specifications

UNSPSC

12352005

Target

Ferroptosis; Mitophagy; Reactive Oxygen Species (ROS)

Related Pathways

Apoptosis; Autophagy; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Field of Research

Cancer

Smiles

CC1=CC=C([P+](CCCCCCCCCCO)(C2=CC=C(C=C2)C)C3=CC=C(C=C3)C)C=C1.[Br-]

Molecular Formula

C31H42BrOP

Molecular Weight

541.54

References & Citations

[1]Huang D, et al. Unexpected Discovery of a Novel Triphenylphosphonium Alkylalcohol That Triggers Cancer Cell Death via Mitophagy and Ferroptosis. J Med Chem. 2025 Jun 12;68 (11) :11852-11874.