MerTK-IN-3

MerTK-IN-3 (compound 11) is an orally active and selectivity MerTK inhibitor with IC50 values of 21.5 nM and 991.3 nM for MerTK and Tyro3, respectively. MerTK-IN-3 can be used for study of colon cancer[1].

Product Specifications

CAS Number

3029898-85-6

UNSPSC

12352005

Target

TAM Receptor

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

O=C(C1=CN(C)N(C2=CC=C(F)C=C2)C1=O)NC3=CC=C(OC4=C5C(OC(C6=CN(C)N=C6)=C5C7=CC=CC(CN(C)C)=C7)=NC=N4)C=C3

Molecular Formula

C36H31FN8O4

Molecular Weight

658.68

References & Citations

[1]Peng YH, et al. Structure-Based Design of Potent and Selective MerTK Inhibitors by Modulating the Conformation of αC Helix. J Med Chem. 2025 Jun 12;68 (11) :10877-10896.