MerTK-IN-3
MerTK-IN-3 (compound 11) is an orally active and selectivity MerTK inhibitor with IC50 values of 21.5 nM and 991.3 nM for MerTK and Tyro3, respectively. MerTK-IN-3 can be used for study of colon cancer[1].
Product Specifications
CAS Number
[3029898-85-6]
UNSPSC
12352005
Target
TAM Receptor
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
O=C(C1=CN(C)N(C2=CC=C(F)C=C2)C1=O)NC3=CC=C(OC4=C5C(OC(C6=CN(C)N=C6)=C5C7=CC=CC(CN(C)C)=C7)=NC=N4)C=C3
Molecular Formula
C36H31FN8O4
Molecular Weight
658.68
References & Citations
[1]Peng YH, et al. Structure-Based Design of Potent and Selective MerTK Inhibitors by Modulating the Conformation of αC Helix. J Med Chem. 2025 Jun 12;68 (11) :10877-10896.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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