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ML-20

ML-20, Malabaricone C analogue, is a autophagy inhibitor and radiosensitizer. ML-20 inhibits cell growth, induces cell apoptosis. ML-20 induces DNA double-strand breaks, loss of mitochondrial membrane potential (MMP), and lysosomal membrane permeabilization (LMP). ML-20 induces endoplasmic reticulum stress and concurrent inhibition of autophagy flux due to LMP.

Product Specifications

UNSPSC

12352005

Target

Apoptosis; Autophagy

Related Pathways

Apoptosis; Autophagy

Applications

COVID-19-immunoregulation

Field of Research

Cancer

Smiles

OC1=CC=C(C=C1O)CCCCCCCCCC2=C(C=CC=C2O)O

Molecular Formula

C21H28O4

Molecular Weight

344.44

References & Citations

[1]Kundu K, et al. Synthesis, Structure-Activity Relationship, and Biological Evaluation of a Novel Malabaricone Derivative: A Potent Anticancer Agent and Radiosensitizer That Targets Autophagy Flux. ACS Omega. 2025 May 21;10 (21) :21589-21608.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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